Review of human immunodeficiency virus type 1-related opportunistic infections in sub-Saharan Africa
- PMID: 12594648
- DOI: 10.1086/367655
Review of human immunodeficiency virus type 1-related opportunistic infections in sub-Saharan Africa
Abstract
Understanding the natural history of human immunodeficiency virus type 1 (HIV-1) and opportunistic infections in sub-Saharan Africa is necessary to optimize strategies for the prophylaxis and treatment of opportunistic infections and to understand the likely impact of antiretroviral therapy. We undertook a systematic review of the literature on HIV-1 infection in sub-Saharan Africa to assess data from recent cohorts and selected cross-sectional studies to delineate rates of opportunistic infections, associated CD4 cell counts, and associated mortality. We searched the MEDLINE database and the Cochrane Database of Systematic Reviews and Cochrane Clinical Trials Register for English-language literature published from 1990 through April 2002. Tuberculosis, bacterial infections, and malaria were identified as the leading causes of HIV-related morbidity across sub-Saharan Africa. Of the few studies that reported CD4 cell counts, the range of cell counts at the time of diagnosis of opportunistic infections was wide. Policies regarding the type and timing of opportunistic infection prophylaxis may be region specific and urgently require further study.
Similar articles
-
Impact of highly active antiretroviral therapy on incidence and management of human immunodeficiency virus-related opportunistic infections.J Antimicrob Chemother. 2004 Nov;54(5):849-53. doi: 10.1093/jac/dkh438. Epub 2004 Sep 29. J Antimicrob Chemother. 2004. PMID: 15456733 Review.
-
[Severe opportunistic infections in HIV-positive adults in sub-Saharan Africa].Med Trop (Mars). 2006 Aug;66(4):343-5. Med Trop (Mars). 2006. PMID: 16999042 French.
-
Prevention of opportunistic infections in adult and adolescent patients with HIV infection. GESIDA/National AIDS Plan guidelines, 2004 [correction].Enferm Infecc Microbiol Clin. 2004 Mar;22(3):160-76. doi: 10.1016/s0213-005x(04)73057-8. Enferm Infecc Microbiol Clin. 2004. PMID: 14987537 Review. English, Spanish.
-
The rate of serious bacterial infections among HIV-infected children with immune reconstitution who have discontinued opportunistic infection prophylaxis.Pediatrics. 2005 Apr;115(4):e488-94. doi: 10.1542/peds.2004-1847. Epub 2005 Mar 16. Pediatrics. 2005. PMID: 15772172 Clinical Trial.
-
Effect of anti retroviral therapy (ART) on CD4 T lymphocyte count and the spectrum of opportunistic infections in HIV/AIDS in Manipur.J Commun Dis. 2009 Mar;41(1):19-24. J Commun Dis. 2009. PMID: 19886171
Cited by
-
Virulence in malaria: an evolutionary viewpoint.Philos Trans R Soc Lond B Biol Sci. 2004 Jun 29;359(1446):965-86. doi: 10.1098/rstb.2003.1414. Philos Trans R Soc Lond B Biol Sci. 2004. PMID: 15306410 Free PMC article. Review.
-
Estimated Burden of Fungal Infections in Namibia.J Fungi (Basel). 2019 Aug 16;5(3):75. doi: 10.3390/jof5030075. J Fungi (Basel). 2019. PMID: 31426392 Free PMC article.
-
Cryptococcal immune reconstitution inflammatory syndrome in HIV-1-infected individuals: proposed clinical case definitions.Lancet Infect Dis. 2010 Nov;10(11):791-802. doi: 10.1016/S1473-3099(10)70170-5. Lancet Infect Dis. 2010. PMID: 21029993 Free PMC article.
-
Epidemiology of Opportunistic Infections in HIV Infected Patients on Treatment in Accredited HIV Treatment Centers in Cameroon.Int J MCH AIDS. 2019;8(2):163-172. doi: 10.21106/ijma.302. Epub 2019 Dec 18. Int J MCH AIDS. 2019. PMID: 32257607 Free PMC article.
-
Cryptococcal meningitis in Senegal: epidemiology, laboratory findings, therapeutic and outcome of cases diagnosed from 2004 to 2011.Mycopathologia. 2013 Dec;176(5-6):443-9. doi: 10.1007/s11046-013-9710-8. Epub 2013 Oct 25. Mycopathologia. 2013. PMID: 24293170
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous
