Review
doi: 10.1016/s1367-5931(98)80061-6.
The active sites of molybdenum- and tungsten-containing enzymes
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- PMID: 9667924
- DOI: 10.1016/s1367-5931(98)80061-6
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Review
The active sites of molybdenum- and tungsten-containing enzymes
Curr Opin Chem Biol.
1998 Apr.
Abstract
Protein X-ray crystallography has revealed the structures of the active sites of several molybdenum- and tungsten-containing enzymes that catalyze formal hydroxylation and oxygen atom transfer reactions. Each molybdenum (or tungsten) atom is coordinated by one (or two) ene-dithiolate groups of a novel pterin (molybdopterin), and the active sites are further differentiated from one another by the number of terminal oxo and/or sulfido groups and by coordinated amino acid residues. These active-site structures have no precedent in the coordination chemistry of molybdenum and tungsten.
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