Unraveling autism

doi:10.1016/j.ajhg.2007.12.003

Comment

. 2008 Jan;82(1):7-9.

doi: 10.1016/j.ajhg.2007.12.003.

Unraveling autism

Dietrich A Stephan¹

Affiliations

PMID: 18179879
PMCID: PMC2253980
DOI: 10.1016/j.ajhg.2007.12.003

Comment

Unraveling autism

Dietrich A Stephan. Am J Hum Genet. 2008 Jan.

. 2008 Jan;82(1):7-9.

doi: 10.1016/j.ajhg.2007.12.003.

Author

Dietrich A Stephan¹

Affiliation

¹ Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA. dstephan@tgen.org

PMID: 18179879
PMCID: PMC2253980
DOI: 10.1016/j.ajhg.2007.12.003

Abstract

In this issue of AJHG, Alarcón et al.,(1) Arking et al.,(2) and Bakkaloglu et al.(3) identify a series of functional variants in the CNTNAP2 gene that unequivocally implicate this gene as causing Type 1 autism in the general population.

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Comment on

Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene.
Alarcón M, Abrahams BS, Stone JL, Duvall JA, Perederiy JV, Bomar JM, Sebat J, Wigler M, Martin CL, Ledbetter DH, Nelson SF, Cantor RM, Geschwind DH. Alarcón M, et al. Am J Hum Genet. 2008 Jan;82(1):150-9. doi: 10.1016/j.ajhg.2007.09.005. Am J Hum Genet. 2008. PMID: 18179893 Free PMC article.
A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism.
Arking DE, Cutler DJ, Brune CW, Teslovich TM, West K, Ikeda M, Rea A, Guy M, Lin S, Cook EH, Chakravarti A. Arking DE, et al. Am J Hum Genet. 2008 Jan;82(1):160-4. doi: 10.1016/j.ajhg.2007.09.015. Am J Hum Genet. 2008. PMID: 18179894 Free PMC article.
Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders.
Bakkaloglu B, O'Roak BJ, Louvi A, Gupta AR, Abelson JF, Morgan TM, Chawarska K, Klin A, Ercan-Sencicek AG, Stillman AA, Tanriover G, Abrahams BS, Duvall JA, Robbins EM, Geschwind DH, Biederer T, Gunel M, Lifton RP, State MW. Bakkaloglu B, et al. Am J Hum Genet. 2008 Jan;82(1):165-73. doi: 10.1016/j.ajhg.2007.09.017. Am J Hum Genet. 2008. PMID: 18179895 Free PMC article.

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Eissa N, Al-Houqani M, Sadeq A, Ojha SK, Sasse A, Sadek B. Eissa N, et al. Front Neurosci. 2018 May 16;12:304. doi: 10.3389/fnins.2018.00304. eCollection 2018. Front Neurosci. 2018. PMID: 29867317 Free PMC article. Review.
Genetic determinants of autism in individuals with deletions of 18q.
O'Donnell L, Soileau B, Heard P, Carter E, Sebold C, Gelfond J, Hale DE, Cody JD. O'Donnell L, et al. Hum Genet. 2010 Aug;128(2):155-64. doi: 10.1007/s00439-010-0839-y. Epub 2010 May 25. Hum Genet. 2010. PMID: 20499253
GABA system dysfunction in autism and related disorders: from synapse to symptoms.
Coghlan S, Horder J, Inkster B, Mendez MA, Murphy DG, Nutt DJ. Coghlan S, et al. Neurosci Biobehav Rev. 2012 Oct;36(9):2044-55. doi: 10.1016/j.neubiorev.2012.07.005. Epub 2012 Jul 25. Neurosci Biobehav Rev. 2012. PMID: 22841562 Free PMC article. Review.
Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder.
Zhou K, Dempfle A, Arcos-Burgos M, Bakker SC, Banaschewski T, Biederman J, Buitelaar J, Castellanos FX, Doyle A, Ebstein RP, Ekholm J, Forabosco P, Franke B, Freitag C, Friedel S, Gill M, Hebebrand J, Hinney A, Jacob C, Lesch KP, Loo SK, Lopera F, McCracken JT, McGough JJ, Meyer J, Mick E, Miranda A, Muenke M, Mulas F, Nelson SF, Nguyen TT, Oades RD, Ogdie MN, Palacio JD, Pineda D, Reif A, Renner TJ, Roeyers H, Romanos M, Rothenberger A, Schäfer H, Sergeant J, Sinke RJ, Smalley SL, Sonuga-Barke E, Steinhausen HC, van der Meulen E, Walitza S, Warnke A, Lewis CM, Faraone SV, Asherson P. Zhou K, et al. Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1392-8. doi: 10.1002/ajmg.b.30878. Am J Med Genet B Neuropsychiatr Genet. 2008. PMID: 18988193 Free PMC article.
Parental occupational exposure to solvents and autism spectrum disorder: An exploratory look at gene-environment interactions.
McCanlies EC, Gu JK, Kashon M, Yucesoy B, Ma CC, Sanderson WT, Kim K, Ludeña-Rodriguez YJ, Hertz-Picciotto I. McCanlies EC, et al. Environ Res. 2023 Jul 1;228:115769. doi: 10.1016/j.envres.2023.115769. Epub 2023 Mar 31. Environ Res. 2023. PMID: 37004853 Free PMC article. No abstract available.

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References

1. Alarcón M., Abrahams B.S., Stone J.L., Duvall J.A., Perederiy J.V., Bomar J.M., Sebat J., Wigler M., Martin C.L., Ledbetter D.H. Am. J. Hum. Genet. 2008;82:150–159. this issue. - PMC - PubMed
1. Arking D.E., Cutler D.J., Brune C.W., Teslovich T.M., West K., Ikeda M., Rea A., Guy M., Lin S., Cook E.H., Chakravarti A. Am. J. Hum. Genet. 2008;82:160–164. this issue. - PMC - PubMed
1. Bakkaloglu B., O'Roak B.J., Louvi A., Gupta A.R., Abelson J.F., Morgan T.M., Chawarska K., Klin A., Ercan-Sencicek A.G., Stillman A.A. Am. J. Hum. Genet. 2008;82:165–173. this issue. - PMC - PubMed
1. Hu-Lince D., Craig D.W., Huentelman M.J., Stephan D.A. Am. J. Pharmacogenomics. 2005;5:233–246. - PubMed
1. Durand C.M., Betancur C., Boeckers T.M., Bockmann J., Chaste P., Fauchereau F., Nygren G., Rastam M., Gillberg I.C., Anckarsäter H. Nat. Genet. 2007;39:25–27. - PMC - PubMed

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[1] Alarcón M., Abrahams B.S., Stone J.L., Duvall J.A., Perederiy J.V., Bomar J.M., Sebat J., Wigler M., Martin C.L., Ledbetter D.H. Am. J. Hum. Genet. 2008;82:150–159. this issue. - PMC - PubMed

[2] Alarcón M., Abrahams B.S., Stone J.L., Duvall J.A., Perederiy J.V., Bomar J.M., Sebat J., Wigler M., Martin C.L., Ledbetter D.H. Am. J. Hum. Genet. 2008;82:150–159. this issue. - PMC - PubMed

[3] Arking D.E., Cutler D.J., Brune C.W., Teslovich T.M., West K., Ikeda M., Rea A., Guy M., Lin S., Cook E.H., Chakravarti A. Am. J. Hum. Genet. 2008;82:160–164. this issue. - PMC - PubMed

[4] Arking D.E., Cutler D.J., Brune C.W., Teslovich T.M., West K., Ikeda M., Rea A., Guy M., Lin S., Cook E.H., Chakravarti A. Am. J. Hum. Genet. 2008;82:160–164. this issue. - PMC - PubMed

[5] Bakkaloglu B., O'Roak B.J., Louvi A., Gupta A.R., Abelson J.F., Morgan T.M., Chawarska K., Klin A., Ercan-Sencicek A.G., Stillman A.A. Am. J. Hum. Genet. 2008;82:165–173. this issue. - PMC - PubMed

[6] Bakkaloglu B., O'Roak B.J., Louvi A., Gupta A.R., Abelson J.F., Morgan T.M., Chawarska K., Klin A., Ercan-Sencicek A.G., Stillman A.A. Am. J. Hum. Genet. 2008;82:165–173. this issue. - PMC - PubMed

[7] Hu-Lince D., Craig D.W., Huentelman M.J., Stephan D.A. Am. J. Pharmacogenomics. 2005;5:233–246. - PubMed

[8] Hu-Lince D., Craig D.W., Huentelman M.J., Stephan D.A. Am. J. Pharmacogenomics. 2005;5:233–246. - PubMed

[9] Durand C.M., Betancur C., Boeckers T.M., Bockmann J., Chaste P., Fauchereau F., Nygren G., Rastam M., Gillberg I.C., Anckarsäter H. Nat. Genet. 2007;39:25–27. - PMC - PubMed

[10] Durand C.M., Betancur C., Boeckers T.M., Bockmann J., Chaste P., Fauchereau F., Nygren G., Rastam M., Gillberg I.C., Anckarsäter H. Nat. Genet. 2007;39:25–27. - PMC - PubMed

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Unraveling autism

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Unraveling autism

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