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Review
. 2009 Nov 7;374(9701):1627-38.
doi: 10.1016/S0140-6736(09)61376-3. Epub 2009 Oct 12.

Autism

Susan E Levy  1 , David S Mandell, Robert T Schultz
Affiliations
Review

Autism

Susan E Levy et al. Lancet. .

Erratum in

  • Lancet. 2011 Oct 29;378(9802):1546

Abstract

Autism spectrum disorders are characterised by severe deficits in socialisation, communication, and repetitive or unusual behaviours. Increases over time in the frequency of these disorders (to present rates of about 60 cases per 10,000 children) might be attributable to factors such as new administrative classifications, policy and practice changes, and increased awareness. Surveillance and screening strategies for early identification could enable early treatment and improved outcomes. Autism spectrum disorders are highly genetic and multifactorial, with many risk factors acting together. Genes that affect synaptic maturation are implicated, resulting in neurobiological theories focusing on connectivity and neural effects of gene expression. Several treatments might address core and comorbid symptoms. However, not all treatments have been adequately studied. Improved strategies for early identification with phenotypic characteristics and biological markers (eg, electrophysiological changes) might hopefully improve effectiveness of treatment. Further knowledge about early identification, neurobiology of autism, effective treatments, and the effect of this disorder on families is needed.

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Conflict of interest statement

Conflicts of interest

We declare that we have no conflicts of interest.

Figures

Figure 1
Figure 1. Stages of identification and diagnosis of autism spectrum disorder
ASD=autism spectrum disorder. Adapted from the National Austictic Society and and the Pennsylvania Department of Public Welfare.
Figure 2
Figure 2. Functional MRI
Functional MRI is used to study activity of the relation of the amygdala to the fusiform face area and superior temporal sulcus (STS), which are responsible for face perception.
Figure 3
Figure 3. Diffusion tensor imaging
Used for measurement of axonal pathways, providing visualisation of connectivity of brain regions.
See this image and copyright information in PMC

Comment in

  • Effectiveness of intensive autism programmes.
    Dawson M, Gernsbacher MA. Dawson M, et al. Lancet. 2010 Feb 27;375(9716):722-3; author reply 723. doi: 10.1016/S0140-6736(10)60299-1. Lancet. 2010. PMID: 20189018 Free PMC article. No abstract available.

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