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Review
. 2010 Jan 26;107 Suppl 1(Suppl 1):1736-41.
doi: 10.1073/pnas.0906080106. Epub 2009 Dec 1.

Evolution in health and medicine Sackler colloquium: Comparative genomics of autism and schizophrenia

Bernard Crespi  1 , Philip Stead, Michael Elliot
Affiliations
Review

Evolution in health and medicine Sackler colloquium: Comparative genomics of autism and schizophrenia

Bernard Crespi et al. Proc Natl Acad Sci U S A. .

Abstract

We used data from studies of copy-number variants (CNVs), single-gene associations, growth-signaling pathways, and intermediate phenotypes associated with brain growth to evaluate four alternative hypotheses for the genomic and developmental relationships between autism and schizophrenia: (i) autism subsumed in schizophrenia, (ii) independence, (iii) diametric, and (iv) partial overlap. Data from CNVs provides statistical support for the hypothesis that autism and schizophrenia are associated with reciprocal variants, such that at four loci, deletions predispose to one disorder, whereas duplications predispose to the other. Data from single-gene studies are inconsistent with a hypothesis based on independence, in that autism and schizophrenia share associated genes more often than expected by chance. However, differentiation between the partial overlap and diametric hypotheses using these data is precluded by limited overlap in the specific genetic markers analyzed in both autism and schizophrenia. Evidence from the effects of risk variants on growth-signaling pathways shows that autism-spectrum conditions tend to be associated with up-regulation of pathways due to loss of function mutations in negative regulators, whereas schizophrenia is associated with reduced pathway activation. Finally, data from studies of head and brain size phenotypes indicate that autism is commonly associated with developmentally-enhanced brain growth, whereas schizophrenia is characterized, on average, by reduced brain growth. These convergent lines of evidence appear most compatible with the hypothesis that autism and schizophrenia represent diametric conditions with regard to their genomic underpinnings, neurodevelopmental bases, and phenotypic manifestations as reflecting under-development versus dysregulated over-development of the human social brain.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Alternative models for the genomic and etiological relationships of autism with schizophrenia and bipolar disorder. (A) Subsumed. (B) Separate. (C) Diametric. (D) Overlapping.
See this image and copyright information in PMC

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