This document outlines 50 principles for scaling web sites. It discusses reducing complexity, distributing workloads, using caching, designing for fault tolerance, and avoiding state. Specific principles covered include reducing unnecessary work, designing for scalability from the start, simplifying solutions iteratively, reducing DNS lookups, and reducing the number of objects where possible to improve performance. The overall message is that scalability requires focusing on simplicity, distribution of work, and optimization of resources.