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Review
. 2014 Feb;101(2):301-9.
doi: 10.1016/j.fertnstert.2013.11.002. Epub 2013 Dec 17.

Fertility in patients with congenital adrenal hyperplasia

David E Reichman  1 , Perrin C White  2 , Maria I New  3 , Zev Rosenwaks  4
Affiliations
Free article
Review

Fertility in patients with congenital adrenal hyperplasia

David E Reichman et al. Fertil Steril. 2014 Feb.
Free article

Abstract

Congenital adrenal hyperplasia (CAH) is the most frequently encountered genetic steroid disorder affecting fertility. Steroid hormones play a crucial role in sexual development and reproductive function; patients with either 21- hydroxylase or 11β-hydroxylase deficiency thus face immense challenges to their fertility. Given the relevance of CAH in reproductive medicine as well as the diagnostic challenges posed by the phenotypic overlap with polycystic ovary syndrome, we review the reproductive pahophysiology of both classic and nonclassic CAH and present contemporary treatment options.

Keywords: 11b-hydroxylase; 21 hydroxylase; CAH; genotype; infertility; phenotype; steroidogenesis.

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