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Review
. 2022 Oct 11:11:e89.
doi: 10.1017/jns.2022.83. eCollection 2022.

The contemporaneous epidemic of chronic, copper deficiency

Leslie M Klevay  1
Affiliations
Review

The contemporaneous epidemic of chronic, copper deficiency

Leslie M Klevay. J Nutr Sci. .

Abstract

The classical deficiency diseases have nearly disappeared from the industrialised world and are thought to be found largely in sub-Saharan Africa and South Asia. More than 80 collected medical articles, mostly from Europe and North America, describe more than 9000 people with low concentrations of copper in organs or tissues or impaired metabolic pathways dependent on copper. More than a dozen articles reveal improved anatomy, chemistry or physiology in more than 1000 patients from supplements containing copper. These criteria are diagnostic of deficiency according to The Oxford Textbook of Medicine. Alzheimer's disease, ischaemic heart disease and osteoporosis receive major emphasis here. However, impaired vision, myelodysplastic syndrome and peripheral neuropathy are mentioned. Copper deficiency probably causes some common, contemporaneous diseases. Advice is provided about opportunities for research. Seemingly authoritative statements concerning the rarity of nutritional deficiency in developed countries are wrong.

Keywords: Alzheimer's disease; Copper deficiency; Ischaemic heart disease; Myelodysplastic syndrome; Osteoporosis; Peripheral neuropathy.

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