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Review
. 2012 Apr;15(3):403-15.
doi: 10.1017/S1461145711000800. Epub 2011 Jun 9.

Evidence-based pharmacotherapy of panic disorder: an update

Neeltje M Batelaan  1 , Anton J L M Van Balkom  1 , Dan J Stein  2
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Free article
Review

Evidence-based pharmacotherapy of panic disorder: an update

Neeltje M Batelaan et al. Int J Neuropsychopharmacol. 2012 Apr.
Free article

Abstract

The evidence-based pharmacotherapy of panic disorder continues to evolve. This paper reviews data on first-line pharmacotherapy, evidence for maintenance treatment, and management options for treatment-refractory patients. A Medline search of research on pharmacotherapy was undertaken, and a previous systematic review on the evidence-based pharmacotherapy of panic disorder was updated. Selective serotonin reuptake inhibitors remain a first-line pharmacotherapy of panic disorder, with the serotonin noradrenaline reuptake inhibitor venlafaxine also an acceptable early option. Temporary co-administration of benzodiazepines can be considered. Maintenance treatment reduces relapse rates, but further research to determine optimal duration is needed. For patients not responding to first-line agents several pharmacotherapy options are available, but there is a notable paucity of data on the optimal choice.

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