Further characterization of the autism susceptibility locus AUTS1 on chromosome 7q
- PMID: 11392322
- DOI: 10.1093/hmg/10.9.973
Further characterization of the autism susceptibility locus AUTS1 on chromosome 7q
Abstract
Autism is a neurodevelopmental disorder that usually arises on the basis of a complex genetic predisposition. The most significant susceptibility region in the first whole genome screen of multiplex families was on chromosome 7q, although this linkage was evident only in UK IMGSAC families. Subsequently all other genome screens of non-UK families have found some evidence of increased allele sharing in an overlapping 40 cM region of 7q. To further characterize this susceptibility locus, linkage analysis has now been completed on 170 multiplex IMGSAC families. Using a 5 cM marker grid, analysis of 125 sib pairs meeting stringent inclusion criteria resulted in a multipoint maximum LOD score (MLS) of 2.15 at D7S477, whereas analysis of all 153 sib pairs generated an MLS of 3.37. The 71 non-UK sib pairs now contribute to this linkage. Linkage disequilibrium mapping identified two regions of association-one lying under the peak of linkage, the other some 27 cM distal. These results are supported in part by findings in independent German and American singleton families.
Similar articles
-
A genomewide screen for autism: strong evidence for linkage to chromosomes 2q, 7q, and 16p.Am J Hum Genet. 2001 Sep;69(3):570-81. doi: 10.1086/323264. Epub 2001 Jul 30. Am J Hum Genet. 2001. PMID: 11481586 Free PMC article.
-
A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium.Hum Mol Genet. 1998 Mar;7(3):571-8. doi: 10.1093/hmg/7.3.571. Hum Mol Genet. 1998. PMID: 9546821
-
A genomewide screen for autism-spectrum disorders: evidence for a major susceptibility locus on chromosome 3q25-27.Am J Hum Genet. 2002 Oct;71(4):777-90. doi: 10.1086/342720. Epub 2002 Aug 21. Am J Hum Genet. 2002. PMID: 12192642 Free PMC article.
-
The genetics of autism.Pediatrics. 2004 May;113(5):e472-86. doi: 10.1542/peds.113.5.e472. Pediatrics. 2004. PMID: 15121991 Review.
-
The molecular genetics of autism.Curr Psychiatry Rep. 2000 Apr;2(2):170-5. doi: 10.1007/s11920-000-0063-x. Curr Psychiatry Rep. 2000. PMID: 11122951 Review.
Cited by
-
A genomewide screen for autism: strong evidence for linkage to chromosomes 2q, 7q, and 16p.Am J Hum Genet. 2001 Sep;69(3):570-81. doi: 10.1086/323264. Epub 2001 Jul 30. Am J Hum Genet. 2001. PMID: 11481586 Free PMC article.
-
A genomewide screen of 345 families for autism-susceptibility loci.Am J Hum Genet. 2003 Oct;73(4):886-97. doi: 10.1086/378778. Epub 2003 Sep 17. Am J Hum Genet. 2003. PMID: 13680528 Free PMC article.
-
Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes.BMC Med Genet. 2004 May 5;5:12. doi: 10.1186/1471-2350-5-12. BMC Med Genet. 2004. PMID: 15128462 Free PMC article.
-
Control of cortical synapse development and plasticity by MET receptor tyrosine kinase, a genetic risk factor for autism.J Neurosci Res. 2020 Nov;98(11):2115-2129. doi: 10.1002/jnr.24542. Epub 2019 Nov 19. J Neurosci Res. 2020. PMID: 31746037 Free PMC article. Review.
-
Genome-wide and Ordered-Subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates.BMC Med Genet. 2005 Jan 12;6:1. doi: 10.1186/1471-2350-6-1. BMC Med Genet. 2005. PMID: 15647115 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
