Review
doi: 10.1016/s0969-2126(00)88333-1.
Wet and dry interfaces: the role of solvent in protein-protein and protein-DNA recognition
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- PMID: 10647173
- DOI: 10.1016/s0969-2126(00)88333-1
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Review
Wet and dry interfaces: the role of solvent in protein-protein and protein-DNA recognition
Structure.
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Abstract
Water molecules are found in abundance in protein-protein and protein-DNA interfaces. Although interface solvent molecules exchange quickly with the bulk solvent, structural and biochemical data suggest that water-mediated interactions are as important as direct hydrogen bonds in the stability and specificity of recognition.
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