Referring to this and parts of the related Python script from https://github.com/AlexFromChaos/synology_hibernation_fixer.

While the Synology DSM HDD hibernation fixer script does a number of different things, I would find what Alex labels "applying in-memory patches for DSM binaries which prevent HDD hibernation to function normally when there is an NVMe activity (allows for eg. to setup noisy Docker containers on an NVMe partition and have working HDD hibernation)" as probably very useful in most cases where Synology_HDD_db is applied. He states explicitly that this goes beyond just Docker usage (and I have observed the same on my unit).

My understanding of Alex' original Reddit post is that this strange behavior was probably introduced w/ SSD Cache in mind. As it is the main point of Synology_HDD_db to actually make the M.2 slots work for normal storage purposes, it would make sense to also integrate the hibernation fix directly here as many people will move their frequently accessed files to the M.2 first (I would expect).

Having this available as an (experimental) option directly in Synology_HDD_db (while giving credit to Alex in the Readme) would be a great addition IMHO.