Effects of Depression and Serotonergic Antidepressants on Bone: Mechanisms and Implications for the Treatment of Depression

doi:10.1007/s40266-015-0323-4

Review

. 2016 Jan;33(1):21-5.

doi: 10.1007/s40266-015-0323-4.

Effects of Depression and Serotonergic Antidepressants on Bone: Mechanisms and Implications for the Treatment of Depression

Brisa S Fernandes^{1

2}, Jason M Hodge^{3

4}, Julie A Pasco^{1

5}, Michael Berk^{1

6}, Lana J Williams⁷

Affiliations

¹ IMPACT Strategic Research Centre, School of Medicine, Deakin University, PO Box 281, Geelong, VIC, 3220, Australia.
² Laboratory of Calcium Binding Proteins in the Central Nervous System, Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
³ Barwon Biomedical Research, Barwon Health University Hospital, Geelong, VIC, Australia.
⁴ MMR Strategic Research Centre, School of Medicine, Deakin University, Geelong, VIC, Australia.
⁵ Department of Medicine, The University of Melbourne, St Albans, VIC, Australia.
⁶ Florey Institute for Neuroscience and Mental Health, Department of Psychiatry and Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Parkville, Australia.
⁷ IMPACT Strategic Research Centre, School of Medicine, Deakin University, PO Box 281, Geelong, VIC, 3220, Australia. lanaw@barwonhealth.org.au.

PMID: 26547857
DOI: 10.1007/s40266-015-0323-4

Review

Effects of Depression and Serotonergic Antidepressants on Bone: Mechanisms and Implications for the Treatment of Depression

Brisa S Fernandes et al. Drugs Aging. 2016 Jan.

. 2016 Jan;33(1):21-5.

doi: 10.1007/s40266-015-0323-4.

Authors

Brisa S Fernandes^{1

2}, Jason M Hodge^{3

4}, Julie A Pasco^{1

5}, Michael Berk^{1

6}, Lana J Williams⁷

Affiliations

¹ IMPACT Strategic Research Centre, School of Medicine, Deakin University, PO Box 281, Geelong, VIC, 3220, Australia.
² Laboratory of Calcium Binding Proteins in the Central Nervous System, Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
³ Barwon Biomedical Research, Barwon Health University Hospital, Geelong, VIC, Australia.
⁴ MMR Strategic Research Centre, School of Medicine, Deakin University, Geelong, VIC, Australia.
⁵ Department of Medicine, The University of Melbourne, St Albans, VIC, Australia.
⁶ Florey Institute for Neuroscience and Mental Health, Department of Psychiatry and Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Parkville, Australia.
⁷ IMPACT Strategic Research Centre, School of Medicine, Deakin University, PO Box 281, Geelong, VIC, 3220, Australia. lanaw@barwonhealth.org.au.

PMID: 26547857
DOI: 10.1007/s40266-015-0323-4

Abstract

Osteoporosis is a chronic skeletal disease marked by microarchitectural deterioration of the bone matrix and depletion of bone mineral density (BMD), with a consequent increased risk for fragility fractures. It has been frequently associated with depression, which is also a chronic and debilitating disorder with high prevalence. Selective serotonin reuptake inhibitors (SSRIs), first-line agents in the pharmacological treatment of mood and anxiety disorders, have also been shown to negatively affect bone metabolism. SSRIs are the most prescribed antidepressants worldwide and a large number of persons at risk of developing osteoporosis, including older patients, will receive these antidepressants. Therefore, a proper musculoskeletal evaluation of individuals who are being targeted for or using SSRIs is a priority. The aim of this article is to review the evidence regarding the effects of depression and serotonergic antidepressants on bone and its implications for clinical care.

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[1] Biol Psychiatry. 2009 Sep 1;66(5):423-32 - PubMed

[2] Biol Psychiatry. 2009 Sep 1;66(5):423-32 - PubMed

[3] Hormones (Athens). 2013 Jul-Sep;12(3):350-62 - PubMed

[4] Hormones (Athens). 2013 Jul-Sep;12(3):350-62 - PubMed

[5] Nat Med. 2011 Jun;17(6):684-91 - PubMed

[6] Nat Med. 2011 Jun;17(6):684-91 - PubMed

[7] J Am Med Dir Assoc. 2012 Jun;13(5):413-7 - PubMed

[8] J Am Med Dir Assoc. 2012 Jun;13(5):413-7 - PubMed

[9] Bone. 2001 Nov;29(5):477-86 - PubMed

[10] Bone. 2001 Nov;29(5):477-86 - PubMed

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Effects of Depression and Serotonergic Antidepressants on Bone: Mechanisms and Implications for the Treatment of Depression

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Effects of Depression and Serotonergic Antidepressants on Bone: Mechanisms and Implications for the Treatment of Depression

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