Review
doi: 10.1016/s0955-0674(00)00231-3.
Lipid and mechano-gated 2P domain K(+) channels
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- PMID: 11454447
- DOI: 10.1016/s0955-0674(00)00231-3
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Review
Lipid and mechano-gated 2P domain K(+) channels
Curr Opin Cell Biol.
2001 Aug.
Abstract
The two pore domain K(+) channels TREK and TRAAK are opened by membrane stretch. The activating mechanical force comes from the bilayer membrane and is independent of the cytoskeleton. Emerging work shows that mechano-gated TREK and TRAAK are opened by various lipids, including long chain polyunsaturated anionic fatty acids and neutral cone-shaped lysophospholipids. TREK-1 shares the properties of the Aplysia neuronal S channel, a presynaptic background K(+) channel involved in behavioral sensitization, a simple form of learning.
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