doi: 10.1016/s1534-5807(02)00327-1.
Centrosome maturation and mitotic spindle assembly in C. elegans require SPD-5, a protein with multiple coiled-coil domains
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- PMID: 12431374
- DOI: 10.1016/s1534-5807(02)00327-1
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Centrosome maturation and mitotic spindle assembly in C. elegans require SPD-5, a protein with multiple coiled-coil domains
Dev Cell.
2002 Nov.
Free article
Abstract
The maternally expressed C. elegans gene spd-5 encodes a centrosomal protein with multiple coiled-coil domains. During mitosis in mutants with reduced levels of SPD-5, microtubules assemble but radiate from condensed chromosomes without forming a spindle, and mitosis fails. SPD-5 is required for the centrosomal localization of gamma-tubulin, XMAP-215, and Aurora A kinase family members, but SPD-5 accumulates at centrosomes in mutants lacking these proteins. Furthermore, SPD-5 interacts genetically with a dynein heavy chain. We propose that SPD-5, along with dynein, is required for centrosome maturation and mitotic spindle assembly.
Comment in
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Centrosomes: coiled-coils organize the cell center.Curr Biol. 2003 Feb 4;13(3):R88-90. doi: 10.1016/s0960-9822(03)00033-2. Curr Biol. 2003. PMID: 12573233
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