Isotretinoin and antidepressant pharmacotherapy: a prescription sequence symmetry analysis
- PMID: 12963905
- DOI: 10.1067/s0190-9622(03)02087-5
Isotretinoin and antidepressant pharmacotherapy: a prescription sequence symmetry analysis
Abstract
Background: Isotretinoin is indicated for the treatment of severe, recalcitrant nodular acne. Spontaneous reports have suggested a possible association between isotretinoin and depression that has not been supported by prior studies. Depression has been reported in patients with acne and is common among adolescents.
Objective: The objective of this study was to investigate whether there is an association between isotretinoin use and onset of depression.
Methods: A large retrospective database study was performed through a review of pharmacy claims to evaluate the order of first-recorded isotretinoin and antidepressant dispensings in incident users. The study included 2821 patients, aged 12 to 49 years, who filled isotretinoin prescriptions between June 1, 1999, and March 31, 2000. The ratio of the number of patients who filled isotretinoin prescription first versus second was computed, with adjustment for variations in physician prescribing patterns; a ratio significantly greater than 1.0 indicates a depression-invoking relationship. Similar analyses of minocycline were performed.
Results: Adjusted ratios for all antidepressants and by class were not significantly greater than 1.0. Similar results were found for minocycline.
Conclusion: The results do not support an association between the use of isotretinoin and the onset of depression.
Similar articles
-
[Depression and panic attack in acne treated with isotretinoin].Semergen. 2012 Apr;38(3):188-91. Semergen. 2012. PMID: 24895726 Spanish.
-
Use of isotretinoin and risk of depression in patients with acne: a systematic review and meta-analysis.BMJ Open. 2019 Jan 21;9(1):e021549. doi: 10.1136/bmjopen-2018-021549. BMJ Open. 2019. PMID: 30670500 Free PMC article.
-
A pilot study evaluating anxiety and depressive scores in acne patients treated with isotretinoin.J Dermatolog Treat. 2004 Jun;15(3):153-7. doi: 10.1080/09546630410027472. J Dermatolog Treat. 2004. PMID: 15204147 Clinical Trial.
-
Important controversies associated with isotretinoin therapy for acne.Am J Clin Dermatol. 2013 Apr;14(2):71-6. doi: 10.1007/s40257-013-0014-z. Am J Clin Dermatol. 2013. PMID: 23559397 Review.
-
Isotretinoin, depression and suicide: a review of the evidence.Br J Gen Pract. 2005 Feb;55(511):134-8. Br J Gen Pract. 2005. PMID: 15720936 Free PMC article. Review.
Cited by
-
The performance of sequence symmetry analysis as a tool for post-market surveillance of newly marketed medicines: a simulation study.BMC Med Res Methodol. 2014 May 15;14:66. doi: 10.1186/1471-2288-14-66. BMC Med Res Methodol. 2014. PMID: 24886247 Free PMC article.
-
Prescribing cascades in community-dwelling adults: A systematic review.Pharmacol Res Perspect. 2022 Oct;10(5):e01008. doi: 10.1002/prp2.1008. Pharmacol Res Perspect. 2022. PMID: 36123967 Free PMC article.
-
Initiation of acetylcholinesterase inhibitors and complications of chronic airways disorders in elderly patients.Drug Saf. 2006;29(11):1077-85. doi: 10.2165/00002018-200629110-00007. Drug Saf. 2006. PMID: 17061913
-
The neurobiology of retinoic acid in affective disorders.Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):315-31. doi: 10.1016/j.pnpbp.2007.07.001. Epub 2007 Jul 10. Prog Neuropsychopharmacol Biol Psychiatry. 2008. PMID: 17707566 Free PMC article. Review.
-
Retinoic acid and affective disorders: the evidence for an association.J Clin Psychiatry. 2012 Jan;73(1):37-50. doi: 10.4088/JCP.10r05993. Epub 2011 Aug 23. J Clin Psychiatry. 2012. PMID: 21903028 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
