Depression: a case of neuronal life and death?
- PMID: 15271581
- DOI: 10.1016/j.biopsych.2004.02.033
Depression: a case of neuronal life and death?
Abstract
Preclinical and clinical studies have demonstrated that stress or depression can lead to atrophy and cell loss in limbic brain structures that are critically involved in depression, including the hippocampus. Studies in experimental animals demonstrate that decreased birth of new neurons in adult hippocampus could contribute to this atrophy. In contrast, antidepressant treatment increases neurogenesis in the hippocampus of adult animals and blocks the effects of stress. Moreover, blockade of hippocampal neurogenesis blocks the actions of antidepressants in behavioral models of depression, demonstrating a direct link between behavior and new cell birth. This perspective reviews the literature in support of the hypothesis that altered birth of new neurons in the adult brain contributes to the etiology and treatment of depression and considers research strategies to test this hypothesis.
Similar articles
-
Regulation of adult hippocampal neurogenesis: relevance to depression.Expert Rev Neurother. 2007 Jul;7(7):853-64. doi: 10.1586/14737175.7.7.853. Expert Rev Neurother. 2007. PMID: 17610392 Review.
-
Cognitive role of neurogenesis in depression and antidepressant treatment.Neuroscientist. 2008 Aug;14(4):326-38. doi: 10.1177/1073858408317242. Epub 2008 Jul 8. Neuroscientist. 2008. PMID: 18612087 Review.
-
Neurogenesis and depression: etiology or epiphenomenon?Biol Psychiatry. 2004 Aug 1;56(3):146-50. doi: 10.1016/j.biopsych.2004.04.011. Biol Psychiatry. 2004. PMID: 15271582 Review.
-
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior.Behav Pharmacol. 2007 Sep;18(5-6):391-418. doi: 10.1097/FBP.0b013e3282ee2aa8. Behav Pharmacol. 2007. PMID: 17762509 Review.
-
A neurogenic theory of depression gains momentum.Mol Interv. 2003 Dec;3(8):441-4. doi: 10.1124/mi.3.8.441. Mol Interv. 2003. PMID: 14993452
Cited by
-
Noninvasive Vagal Nerve Stimulation for Opioid Use Disorder.Ann Depress Anxiety. 2023;10(1):1117. Epub 2023 Aug 2. Ann Depress Anxiety. 2023. PMID: 38074313 Free PMC article.
-
Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism.Exp Ther Med. 2012 Oct;4(4):627-632. doi: 10.3892/etm.2012.669. Epub 2012 Aug 16. Exp Ther Med. 2012. PMID: 23170116 Free PMC article.
-
The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice.Psychopharmacology (Berl). 2008 Jan;195(4):547-57. doi: 10.1007/s00213-007-0945-2. Epub 2007 Sep 22. Psychopharmacology (Berl). 2008. PMID: 17891380
-
Antidepressant effects of exercise: evidence for an adult-neurogenesis hypothesis?J Psychiatry Neurosci. 2006 Mar;31(2):84-92. J Psychiatry Neurosci. 2006. PMID: 16575423 Free PMC article. Review.
-
Noise trauma impairs neurogenesis in the rat hippocampus.Neuroscience. 2010 Jun 2;167(4):1216-26. doi: 10.1016/j.neuroscience.2010.02.071. Epub 2010 Mar 3. Neuroscience. 2010. PMID: 20206235 Free PMC article.
Publication types
MeSH terms
Substances
Supplementary concepts
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
