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Clinical Trial
. 2005 Apr;7(4 Suppl 1):27-31.
doi: 10.1111/j.1524-6175.2005.04450.x.

Comparison of blood pressure control with amlodipine and controlled-release isradipine: an open-label, drug substitution study

Michael Ganz  1 , Rasoul Mokabberi, Domenic A Sica
Affiliations
Clinical Trial

Comparison of blood pressure control with amlodipine and controlled-release isradipine: an open-label, drug substitution study

Michael Ganz et al. J Clin Hypertens (Greenwich). 2005 Apr.

Abstract

An open-label drug substitution study showed that controlled-release isradipine (Dynacirc-CR) can be safely substituted for amlodipine on a mg-for-mg basis in patients with mild-to-moderate hypertension. When controlled-release isradipine was substituted for amlodipine, blood pressure was more effectively controlled, and edema rates were reduced. When subjects resumed amlodipine therapy, the previous gain in blood pressure reduction and lessening of edema vanished. The basis for this more favorable pattern of efficacy and side-effects with controlled-release isradipine, although mechanistically unresolved, may relate to a lesser degree of sympathetic nervous system activation.

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Figures

Figure 1
Figure 1
Isradipine‐controlled release (CR) substitution study trial design. Following a 6‐month run‐in period, amlodipine‐treated patients were converted to an equivalent dose of isradipine‐CR for 6 weeks. After 6 weeks of isradipine‐CR treatment, patients resumed therapy with amlodipine for an additional 6 weeks. BP=blood pressure
Figure 1
Figure 1
Comparative edema rate at 5‐ and 10‐mg doses of amlodipine and controlled‐release (CR) isradipine. CR=contolled release; *p
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