Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 May;89(2):247-9.
doi: 10.1007/BF00217134.

Evidence for an ancestral alphoid domain on the long arm of human chromosome 2

R Avarello  1 , A Pedicini, A Caiulo, O Zuffardi, M Fraccaro
Affiliations

Evidence for an ancestral alphoid domain on the long arm of human chromosome 2

R Avarello et al. Hum Genet. 1992 May.

Abstract

In situ hybridization, under low stringency conditions with two alphoid DNA probes (pY alpha 1 and p82H) labeled with digoxigenin-dUTP, decorated all the centromeres of the human karyotype. However, signals were also detected on the long arm of chromosome 2 at approximately q21.3-q22.1. Since it is supposed that human chromosome 2 originated by the telomeric fusion of two ancestral primate chromosomes, these findings indicate that not only the telomeric sequences, but also the ancestral centromere (or at least its alphoid sequences), have been conserved.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Mol Biol. 1987 Jun 5;195(3):457-70 - PubMed
    1. Cancer Genet Cytogenet. 1990 Jan;44(1):37-45 - PubMed
    1. Hum Genet. 1988 Jan;78(1):27-32 - PubMed
    1. Hum Genet. 1990 Oct;85(5):491-4 - PubMed
    1. Chromosoma. 1973;43(4):423-44 - PubMed

Publication types