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Clinical Trial
. 2005 Jul;42(4):417-27.
doi: 10.1111/j.1469-8986.2005.00299.x.

Distinct M50 and M100 auditory gating deficits in schizophrenia

Faith M Hanlon  1 , Gregory A Miller, Robert J Thoma, Jessica Irwin, Aaron Jones, Sandra N Moses, Mingxiong Huang, Michael P Weisend, Kim M Paulson, J Christopher Edgar, Lawrence E Adler, Jose M Cañive
Affiliations
Clinical Trial

Distinct M50 and M100 auditory gating deficits in schizophrenia

Faith M Hanlon et al. Psychophysiology. 2005 Jul.

Abstract

The time course of the schizophrenia auditory gating deficit may provide clues to mechanisms of impaired cognition. Magnetoencephalography was recorded during a standard paired-click paradigm. Using source strength of the M50 and M100 components for each click, calculated from dipole locations identified as underlying each component for the first click, a ratio of the second divided by the first was used to measure gating. Patients showed a left-hemisphere gating deficit in M50 and a bilateral gating deficit in M100. Hypothesizing that an early deficit may affect later processing, hierarchical regression was used to examine variance shared between the components. A left-hemisphere M100 gating deficit was coupled with the left M50 gating deficit. In contrast, a right-hemisphere M100 gating deficit was unrelated to M50 gating in either hemisphere. Investigations of interhemisphere gating relations may clarify group differences in regional connectivity and their role in gating.

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