Review
doi: 10.1124/pr.57.4.4.
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels
Affiliations
- PMID: 16382098
- DOI: 10.1124/pr.57.4.4
Item in Clipboard
Review
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels
Pharmacol Rev.
2005 Dec.
Abstract
The family of voltage-gated sodium channels initiates action potentials in all types of excitable cells. Nine members of the voltage-gated sodium channel family have been characterized in mammals, and a 10th member has been recognized as a related protein. These distinct sodium channels have similar structural and functional properties, but they initiate action potentials in different cell types and have distinct regulatory and pharmacological properties. This article presents the molecular relationships and physiological roles of these sodium channel proteins and provides comprehensive information on their molecular, genetic, physiological, and pharmacological properties.
Similar articles
-
International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.Pharmacol Rev. 2005 Dec;57(4):411-25. doi: 10.1124/pr.57.4.5. Pharmacol Rev. 2005. PMID: 16382099 Review.
-
State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.Mol Pharmacol. 2008 Mar;73(3):940-8. doi: 10.1124/mol.107.041541. Epub 2007 Dec 13. Mol Pharmacol. 2008. PMID: 18079277 Free PMC article.
-
International Union of Pharmacology. XXXIX. Compendium of voltage-gated ion channels: sodium channels.Pharmacol Rev. 2003 Dec;55(4):575-8. doi: 10.1124/pr.55.4.7. Pharmacol Rev. 2003. PMID: 14657413 Review.
-
n-Alcohols inhibit voltage-gated Na+ channels expressed in Xenopus oocytes.J Pharmacol Exp Ther. 2008 Jul;326(1):270-7. doi: 10.1124/jpet.108.138370. Epub 2008 Apr 23. J Pharmacol Exp Ther. 2008. PMID: 18434586 Free PMC article.
-
Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes.Mol Pharmacol. 2006 Feb;69(2):419-29. doi: 10.1124/mol.105.015941. Epub 2005 Nov 2. Mol Pharmacol. 2006. PMID: 16267209
Cited by
-
Design, Synthesis, and Pharmacological Evaluation of Analogues Derived from the PLEV Tetrapeptide as Protein-Protein Interaction Modulators of Voltage-Gated Sodium Channel 1.6.J Med Chem. 2020 Oct 22;63(20):11522-11547. doi: 10.1021/acs.jmedchem.0c00531. Epub 2020 Oct 15. J Med Chem. 2020. PMID: 33054193 Free PMC article.
-
Engineering prokaryotic channels for control of mammalian tissue excitability.Nat Commun. 2016 Oct 18;7:13132. doi: 10.1038/ncomms13132. Nat Commun. 2016. PMID: 27752065 Free PMC article.
-
Roles of Microglial Ion Channel in Neurodegenerative Diseases.J Clin Med. 2021 Mar 17;10(6):1239. doi: 10.3390/jcm10061239. J Clin Med. 2021. PMID: 33802786 Free PMC article. Review.
-
Single-Molecule Imaging of Nav1.6 on the Surface of Hippocampal Neurons Reveals Somatic Nanoclusters.Biophys J. 2016 Sep 20;111(6):1235-1247. doi: 10.1016/j.bpj.2016.08.016. Biophys J. 2016. PMID: 27653482 Free PMC article.
-
Structure and Function of Ion Channels Regulating Sperm Motility-An Overview.Int J Mol Sci. 2021 Mar 23;22(6):3259. doi: 10.3390/ijms22063259. Int J Mol Sci. 2021. PMID: 33806823 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
