Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Feb;138(2):427-40.

Enhanced expression of neural cell adhesion molecules and tenascin (cytotactin) during wound healing

C M Chuong  1 , H M Chen
Affiliations

Enhanced expression of neural cell adhesion molecules and tenascin (cytotactin) during wound healing

C M Chuong et al. Am J Pathol. 1991 Feb.

Abstract

Both neural cell adhesion molecules (N-CAM) and tenascin (cytotactin) are important in embryonic morphogenesis but their expression is reduced greatly in adults. This study examined whether they are induced during wound healing. The spatial and temporal expression patterns of these two and other adhesion molecules in the healing of skin, cartilage, and tendon were compared. Neural cell adhesion molecules, tenascin, and fibronectin are induced in the granulation tissue but the order of prevalence is fibronectin, tenascin, N-CAM. The order of appearance is N-CAM and fibronectin, and then tenascin. The order of disappearance is N-CAM, tenascin, fibronectin. Liver cell adhesion molecules are present in the epidermis undergoing re-epithelization. Explant cultures showed that N-CAM and tenascin are synthesized by wound fibroblasts. These results suggest that N-CAM and tenascin, widely used in embryonic morphogenesis, are induced in a variety of connective tissues during wound healing.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4894-7 - PubMed
    1. J Cell Biol. 1986 Sep;103(3):929-45 - PubMed
    1. N Engl J Med. 1989 Jul 13;321(2):76-9 - PubMed
    1. Cell. 1989 Jan 13;56(1):93-101 - PubMed
    1. J Exp Med. 1988 Mar 1;167(3):974-87 - PubMed

Publication types

MeSH terms