doi: 10.1212/01.wnl.0000250330.44291.54.
Cognitive prognosis of patients with tuberous sclerosis complex
Affiliations
- PMID: 17200495
- DOI: 10.1212/01.wnl.0000250330.44291.54
Item in Clipboard
Cognitive prognosis of patients with tuberous sclerosis complex
Neurology.
.
Abstract
To assess cognitive outcome in patients with tuberous sclerosis complex (TSC) and identify predictive risk factors, we reviewed records of 107 patients who underwent comprehensive neuropsychiatric evaluation. Fifty-seven percent of patients with TSC had normal-range IQ/developmental quotient (DQ). Cognitive outcome was strongly associated with refractory seizures and TSC2 mutation. In TSC, IQ/DQ is bimodally distributed, and more than half of individuals are in the normal range.
Similar articles
-
Overlapping neurologic and cognitive phenotypes in patients with TSC1 or TSC2 mutations.Neurology. 2008 Mar 18;70(12):908-15. doi: 10.1212/01.wnl.0000280578.99900.96. Epub 2007 Nov 21. Neurology. 2008. PMID: 18032745
-
Tuberous sclerosis complex: genotype/phenotype correlation of retinal findings.Ophthalmology. 2012 Sep;119(9):1917-23. doi: 10.1016/j.ophtha.2012.03.020. Epub 2012 May 16. Ophthalmology. 2012. PMID: 22608477
-
Cyst-like tubers are associated with TSC2 and epilepsy in tuberous sclerosis complex.Neurology. 2009 Mar 31;72(13):1165-9. doi: 10.1212/01.wnl.0000345365.92821.86. Neurology. 2009. PMID: 19332694
-
[Tuberous sclerosis. Apropos of 22 cases].Rev Med Univ Navarra. 1997 Jul-Sep;41(3):152-8. Rev Med Univ Navarra. 1997. PMID: 10420920 Review. Spanish.
-
Tuberous sclerosis complex: disease modifiers and treatments.Curr Opin Pediatr. 2008 Dec;20(6):628-33. doi: 10.1097/MOP.0b013e328318c529. Curr Opin Pediatr. 2008. PMID: 19005330 Review.
Cited by
-
A magnetic resonance imaging study of cerebellar volume in tuberous sclerosis complex.Pediatr Neurol. 2013 Feb;48(2):105-10. doi: 10.1016/j.pediatrneurol.2012.10.011. Pediatr Neurol. 2013. PMID: 23337002 Free PMC article.
-
Epilepsy and Language Development in 8-36-Month-Old Toddlers with Tuberous Sclerosis Complex.J Clin Med. 2022 Aug 4;11(15):4564. doi: 10.3390/jcm11154564. J Clin Med. 2022. PMID: 35956179 Free PMC article.
-
Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex.Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):E1070-9. doi: 10.1073/pnas.1106454108. Epub 2011 Oct 24. Proc Natl Acad Sci U S A. 2011. PMID: 22025691 Free PMC article.
-
Current management of tuberous sclerosis complex.Paediatr Drugs. 2008;10(5):299-313. doi: 10.2165/00148581-200810050-00004. Paediatr Drugs. 2008. PMID: 18754697 Review.
-
Recommendations for the radiological diagnosis and follow-up of neuropathological abnormalities associated with tuberous sclerosis complex.J Neurooncol. 2014 Jun;118(2):205-223. doi: 10.1007/s11060-014-1429-y. Epub 2014 Apr 27. J Neurooncol. 2014. PMID: 24771286
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
