Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2006 Jul;142(1):76-9.
doi: 10.1007/s10517-006-0296-8.

Effect of 5-HT2C receptor antagonist RS 102221 on mouse behavior

[Article in English, Russian]
E G Kuznetsova  1 , T G Amstislavskaya, E A Shefer, N K Popova
Affiliations
Comparative Study

Effect of 5-HT2C receptor antagonist RS 102221 on mouse behavior

[Article in English, Russian]
E G Kuznetsova et al. Bull Exp Biol Med. 2006 Jul.

Abstract

Injection of RS 102221 (selective antagonist of serotonin 5-HT2C receptors) in a dose of 2 mg/kg reduced anxiety of mice in the light-darkness test and decreased the amplitude of the startle reflex. RS 102221 in a dose of 1 mg/kg reduced prestimulus inhibition of the startle reflex. No behavioral changes in Porsolt test and motor activity in the open field test were detected. Hence, RS 102221 is characterized by selective anxiolytic activity, and 5-HT2C receptors are involved in the mechanisms of anxiety and startle reflex formation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

Publication types

Substances