Review
doi: 10.1016/j.cell.2007.08.005.
Living with p53, dying of p53
Affiliations
- PMID: 17719538
- DOI: 10.1016/j.cell.2007.08.005
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Review
Living with p53, dying of p53
Cell.
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Free article
Abstract
The p53 tumor suppressor protein acts as a major defense against cancer. Among its most distinctive features is the ability to elicit both apoptotic death and cell cycle arrest. In this issue of Cell, Das et al. (2007) and Tanaka et al. (2007) provide new insights into the mechanisms that dictate the life and death decisions of p53.
Comment on
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Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation.Cell. 2007 Aug 24;130(4):624-37. doi: 10.1016/j.cell.2007.06.013. Cell. 2007. PMID: 17719541 Free PMC article.
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hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes.Cell. 2007 Aug 24;130(4):638-50. doi: 10.1016/j.cell.2007.08.001. Cell. 2007. PMID: 17719542
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