Rho GTPases: functions and association with cancer

doi:10.1007/s10585-007-9119-1

Review

. 2007;24(8):657-72.

doi: 10.1007/s10585-007-9119-1. Epub 2007 Nov 14.

Rho GTPases: functions and association with cancer

Saskia I J Ellenbroek¹, John G Collard

Affiliations

PMID: 18000759
DOI: 10.1007/s10585-007-9119-1

Review

Rho GTPases: functions and association with cancer

Saskia I J Ellenbroek et al. Clin Exp Metastasis. 2007.

. 2007;24(8):657-72.

doi: 10.1007/s10585-007-9119-1. Epub 2007 Nov 14.

Authors

Saskia I J Ellenbroek¹, John G Collard

Affiliation

¹ Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

PMID: 18000759
DOI: 10.1007/s10585-007-9119-1

Abstract

Rho GTPases are small proteins that act as binary molecular switches in a wide range of signalling pathways upon stimulation of cell surface receptors. Three different classes of regulatory proteins control their activity. In the activated state small GTPases are able to bind a variety of effector proteins and initiate downstream signalling. Rho GTPases regulate important cellular processes ranging from cytoskeletal remodelling and gene expression to cell proliferation and membrane trafficking. Therefore it is not surprising that deregulated Rho signalling can contribute to disturbed cellular phenotypes in a wide range of diseases. The main focus of this review will be the diversity of functions of Rho GTPases and the effects of aberrant Rho GTPase signalling in various aspects of cancer.

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References

1. Nat Cell Biol. 2005 Mar;7(3):270-7 - PubMed
1. Br J Cancer. 2002 Sep 9;87(6):635-44 - PubMed
1. Breast Cancer Res Treat. 2004 Mar;84(1):33-42 - PubMed
1. Mol Cell Biol. 2005 Jul;25(13):5777-85 - PubMed
1. J Cell Biol. 2005 Sep 26;170(7):1029-37 - PubMed

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[1] Nat Cell Biol. 2005 Mar;7(3):270-7 - PubMed

[2] Nat Cell Biol. 2005 Mar;7(3):270-7 - PubMed

[3] Br J Cancer. 2002 Sep 9;87(6):635-44 - PubMed

[4] Br J Cancer. 2002 Sep 9;87(6):635-44 - PubMed

[5] Breast Cancer Res Treat. 2004 Mar;84(1):33-42 - PubMed

[6] Breast Cancer Res Treat. 2004 Mar;84(1):33-42 - PubMed

[7] Mol Cell Biol. 2005 Jul;25(13):5777-85 - PubMed

[8] Mol Cell Biol. 2005 Jul;25(13):5777-85 - PubMed

[9] J Cell Biol. 2005 Sep 26;170(7):1029-37 - PubMed

[10] J Cell Biol. 2005 Sep 26;170(7):1029-37 - PubMed

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Rho GTPases: functions and association with cancer

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Rho GTPases: functions and association with cancer

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