Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jan;27(1):144-8.
doi: 10.1016/j.etap.2008.09.007. Epub 2008 Oct 19.

In vitro metabolism of norbormide in rat, mouse and guinea pig liver preparations

Shanthinie Ravindran  1 , Brian Hopkins, Sergio Bova, David Rennison, Margaret Brimble, Malcolm Tingle
Affiliations

In vitro metabolism of norbormide in rat, mouse and guinea pig liver preparations

Shanthinie Ravindran et al. Environ Toxicol Pharmacol. 2009 Jan.

Abstract

Differences between species in response to norbormide (NRB) may arise through differential pharmacodynamic and/or pharmacokinetic properties. We hypothesise that species-selectivity is at least partly determined by differences in metabolism based on in vitro data generated in liver preparations from rats, mice and guinea pigs. HPLC separation and LC/MS identification revealed that NRB undergoes metabolism primarily to hydroxylated form that was tentatively identified in both rat and non-rat species with NADPH as the preferred cofactor. However, the metabolic profile and the rate are different between species. Gender differences are also reported in the metabolic rate in rats and we postulate that this may be responsible for different toxic sensitivities seen between sexes. Using this knowledge, we aim to develop pharmacological tool(s) for use in designing a new class of drugs that can be targeted in a tissue-selective manner. Further in vivo pharmacokinetic with receptor affinity studies are warranted.

PubMed Disclaimer

Similar articles

See all similar articles

LinkOut - more resources