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Review
. 2012 Jan;14(1):69-76.
doi: 10.1038/aja.2011.69. Epub 2011 Dec 12.

Advanced paternal age and reproductive outcome

Zofnat Wiener-Megnazi  1 , Ron Auslender, Martha Dirnfeld
Affiliations
Review

Advanced paternal age and reproductive outcome

Zofnat Wiener-Megnazi et al. Asian J Androl. 2012 Jan.

Abstract

Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspects are clinically applied during fertility and pregestational counseling. Male aging and reproductive outcome has gained relatively less attention. The purpose of this review is to evaluate updated and relevant literature on the effect of paternal age on reproductive outcome.

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Figures

Figure 1
Figure 1
Trends in paternal age for live births within marriage in England and Wales, 1993–2003: (a) decreasing trends (<35 years); (b) increasing trends (35–54 years). Source: Birth Statistics, England and Wales, Series FM1 no. 32 (Office for National Statistics, 2003). (Births to fathers over 54 years account for less than 0.5% of live births within marriages and are not shown.) Reproduced with permission from Ref. 4.
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