Deleterious effects of selective serotonin reuptake inhibitor treatment on semen parameters in patients with lifelong premature ejaculation
- PMID: 22573230
- DOI: 10.1038/ijir.2012.12
Deleterious effects of selective serotonin reuptake inhibitor treatment on semen parameters in patients with lifelong premature ejaculation
Abstract
Premature ejaculation (PE), the most common sexual dysfunctions in men, is characterized by loss or absence of ejaculatory control. PE can be classified as either a lifelong or acquired condition. Although the prevalence of lifelong PE is rather low in the general male population, recent studies demonstrated that the patients who seek treatment for their rapid ejaculation mostly report lifelong PE. Although no drug for PE has been approved by regulatory bodies, chronic selective serotonin reuptake inhibitors (SSRIs) proved to be effective in treating lifelong PE. Despite the rising use and known effects of antidepressants on ejaculation, only a few reports have evaluated the impact of these drugs on the male fertility. Thus, the aim of this review is to evaluate the efficacy and adverse effects of SSRIs on semen parameters of patients with lifelong PE as well as to assess the safety of this treatment among sexually active couples who desire to have a child.
Similar articles
-
Escitalopram treatment for premature ejaculation has a negative effect on semen parameters.Int J Impot Res. 2011 Nov-Dec;23(6):257-61. doi: 10.1038/ijir.2011.35. Epub 2011 Jul 21. Int J Impot Res. 2011. PMID: 21776003
-
Pharmacotherapy for premature ejaculation.Expert Opin Pharmacother. 2015;16(17):2615-24. doi: 10.1517/14656566.2015.1096928. Epub 2015 Nov 18. Expert Opin Pharmacother. 2015. PMID: 26579971 Review.
-
Drug treatment options for premature ejaculation.Expert Opin Pharmacother. 2018 Jul;19(10):1077-1085. doi: 10.1080/14656566.2018.1494725. Epub 2018 Jul 20. Expert Opin Pharmacother. 2018. PMID: 30028639 Review.
-
Compliance With Fluoxetine Use in Men With Primary Premature Ejaculation.J Sex Med. 2019 Dec;16(12):1895-1899. doi: 10.1016/j.jsxm.2019.09.017. Epub 2019 Nov 15. J Sex Med. 2019. PMID: 31735615 Free PMC article.
-
Oral agents for the treatment of premature ejaculation: review of efficacy and safety in the context of the recent International Society for Sexual Medicine criteria for lifelong premature ejaculation.J Sex Med. 2011 Oct;8(10):2707-25. doi: 10.1111/j.1743-6109.2011.02386.x. Epub 2011 Jul 19. J Sex Med. 2011. PMID: 21771283 Review.
Cited by
-
Clomiphene Effects on Idiopathic Premature Ejaculation.Nephrourol Mon. 2015 Sep 16;7(5):e27281. doi: 10.5812/numonthly.27281. eCollection 2015 Sep. Nephrourol Mon. 2015. PMID: 26543830 Free PMC article.
-
Progresses in pharmaceutical and surgical management of premature ejaculation.Chin Med J (Engl). 2019 Oct 5;132(19):2362-2372. doi: 10.1097/CM9.0000000000000433. Chin Med J (Engl). 2019. PMID: 31567373 Free PMC article. Review.
-
Double Trouble: An Unusual Presentation of Bilateral Penile Fracture.Cureus. 2024 Jun 29;16(6):e63440. doi: 10.7759/cureus.63440. eCollection 2024 Jun. Cureus. 2024. PMID: 39077247 Free PMC article.
-
Current and emerging treatment options for premature ejaculation.Nat Rev Urol. 2022 Nov;19(11):659-680. doi: 10.1038/s41585-022-00639-5. Epub 2022 Aug 25. Nat Rev Urol. 2022. PMID: 36008555 Review.
-
Advances in treating premature ejaculation.F1000Prime Rep. 2014 Jul 8;6:55. doi: 10.12703/P6-55. eCollection 2014. F1000Prime Rep. 2014. PMID: 25184045 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
