Regulation of trophoblast invasion: the role of matrix metalloproteinases
Affiliations
- PMID: 23483768
- PMCID: PMC3594863
Item in Clipboard
Regulation of trophoblast invasion: the role of matrix metalloproteinases
Rev Obstet Gynecol.
2012.
Abstract
Pregnancy success is determined by a complex progress that includes trophoblast invasion and placentation. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are metal-dependent endopeptidases capable of degrading extracellular matrix, and appear to play a critical role in trophoblast invasion. This article reviews in detail the role of MMPs, TIMPs, and their regulators in the mechanism of trophoblast invasion in early human pregnancy.
Keywords: Matrix metalloproteinases; Placenta; Tissue inhibitors of metalloproteinases; Trophoblast invasion.
Similar articles
-
N-acetylglucosaminyltransferase V inhibits the invasion of trophoblast cells by attenuating MMP2/9 activity in early human pregnancy.Placenta. 2015 Nov;36(11):1291-9. doi: 10.1016/j.placenta.2015.08.014. Epub 2015 Sep 1. Placenta. 2015. PMID: 26349781
-
Expression and localization of matrix metalloproteinases (MT1-MMP, MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) during synepitheliochorial placentation of goats (Capra hircus).Placenta. 2004 Nov;25(10):810-9. doi: 10.1016/j.placenta.2004.03.007. Placenta. 2004. PMID: 15451196
-
Mouse trophoblastic cell lines: II--Relationship between invasive potential and proteases.In Vivo. 1998 Mar-Apr;12(2):209-17. In Vivo. 1998. PMID: 9627804
-
Paracrine and autocrine regulators of trophoblast invasion--a review.Placenta. 2000 Mar-Apr;21 Suppl A:S55-60. doi: 10.1053/plac.2000.0521. Placenta. 2000. PMID: 10831123 Review.
-
[Molecular biology of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), and the regulation of these genes in tumor tissues].Nihon Rinsho. 1995 Jul;53(7):1791-7. Nihon Rinsho. 1995. PMID: 7630021 Review. Japanese.
Cited by
-
Uterine Vascular Control Preconception and During Pregnancy.Compr Physiol. 2021 Jun 1;11(3):1871-1893. doi: 10.1002/cphy.c190015. Compr Physiol. 2021. PMID: 34061977 Free PMC article.
-
The YY1/MMP2 axis promotes trophoblast invasion at the maternal-fetal interface.J Pathol. 2016 May;239(1):36-47. doi: 10.1002/path.4694. Epub 2016 Mar 27. J Pathol. 2016. PMID: 27071480 Free PMC article.
-
Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts.Toxicol Sci. 2019 Jan 1;167(1):211-226. doi: 10.1093/toxsci/kfy230. Toxicol Sci. 2019. PMID: 30202865 Free PMC article.
-
(Dis)similarities between the Decidual and Tumor Microenvironment.Biomedicines. 2022 May 4;10(5):1065. doi: 10.3390/biomedicines10051065. Biomedicines. 2022. PMID: 35625802 Free PMC article. Review.
-
Superovulation alters the expression of endometrial genes critical to tissue remodeling and placentation.J Assist Reprod Genet. 2018 Oct;35(10):1799-1808. doi: 10.1007/s10815-018-1244-z. Epub 2018 Jun 29. J Assist Reprod Genet. 2018. PMID: 29959621 Free PMC article.
References
-
- Pijnenborg R, Robertson WB, Brosens I, Dixon G. Review article: trophoblast invasion and the establishment of haemochorial placentation in man and laboratory animals. Placenta. 1981;2:71–91. - PubMed
-
- Bulla R, Bossi F, Fischetti F, et al. The complement system at the fetomaternal interface. Chem Immunol Allergy. 2005;89:149–157. - PubMed
-
- Fitzgerald JS, Poehlmann TG, Schleussner E, Markert UR. Trophoblast invasion: the role of intracellular cytokine signalling via signal transducer and activator of transcription 3 (STAT3) Hum Reprod Update. 2008;14:335–344. - PubMed
-
- Pang ZJ, Zhou JG, Huang LP. Interleukin-10 may participate in regulating trophoblast invasion. Immunol. 2008;60:19–25. - PubMed
-
- Cohen M, Wuillemin C, Chai SY, Bischof P. Effects of ligands or substrate of insulin-regulated aminopeptidase (IRAP) on trophoblast invasion. J Pept Sci. 2008;14:883–887. - PubMed
LinkOut - more resources
Full Text Sources
Other Literature Sources