Horizontal gene transfer in human pathogens
- PMID: 23862575
- DOI: 10.3109/1040841X.2013.804031
Horizontal gene transfer in human pathogens
Abstract
Horizontal gene transfer has a tremendous impact on the genome plasticity, adaptation and evolution of bacteria. Horizontally transferred mobile genetic elements are involved in the dissemination of antibiotic resistance and virulence genes, thus contributing to the emergence of novel "superbugs". This review provides update on various mechanisms of horizontal gene transfer and examines how horizontal gene transfer contributes to the evolution of pathogenic bacteria. Special focus is paid to the role horizontal gene transfer plays in pathogenicity of the emerging human pathogens: hypervirulent Clostridium difficile and Escherichia coli (including the most recent haemolytic uraemic syndrome outbreak strain) and methicillin-resistant Staphylococcus aureus (MRSA), which have been associated with largest outbreaks of infection recently.
Keywords: Clostridium difficile; Escherichia coli; Staphylococcus aureus; horizontal gene transfer; pathogenicity.
Similar articles
-
The impact of horizontal gene transfer on the biology of Clostridium difficile.Adv Microb Physiol. 2014;65:63-82. doi: 10.1016/bs.ampbs.2014.08.002. Epub 2014 Nov 4. Adv Microb Physiol. 2014. PMID: 25476764 Review.
-
Horizontally transferred genetic elements and their role in pathogenesis of bacterial disease.Vet Pathol. 2014 Mar;51(2):328-40. doi: 10.1177/0300985813511131. Epub 2013 Dec 6. Vet Pathol. 2014. PMID: 24318976 Review.
-
The social evolution of bacterial pathogenesis.Proc Biol Sci. 2001 Jan 7;268(1462):61-9. doi: 10.1098/rspb.2000.1330. Proc Biol Sci. 2001. PMID: 12123299 Free PMC article.
-
Horizontal gene transfer of virulence determinants in selected bacterial foodborne pathogens.Food Chem Toxicol. 2009 May;47(5):969-77. doi: 10.1016/j.fct.2008.02.007. Epub 2008 Feb 15. Food Chem Toxicol. 2009. PMID: 18420327 Review.
-
Pathogenicity islands and phage conversion: evolutionary aspects of bacterial pathogenesis.Int J Med Microbiol. 2000 Oct;290(6):519-27. doi: 10.1016/S1438-4221(00)80017-X. Int J Med Microbiol. 2000. PMID: 11100826 Review.
Cited by
-
Gain and loss of antibiotic resistant genes in multidrug resistant bacteria: One Health perspective.J Microbiol. 2021 Jun;59(6):535-545. doi: 10.1007/s12275-021-1085-9. Epub 2021 Apr 20. J Microbiol. 2021. PMID: 33877574 Review.
-
Revisiting typing systems for group B Streptococcus prophages: an application in prophage detection and classification in group B Streptococcus isolates from Argentina.Microb Genom. 2024 Oct;10(10):001297. doi: 10.1099/mgen.0.001297. Microb Genom. 2024. PMID: 39418095 Free PMC article.
-
In Vivo Virulence Characterization of Pregnancy-Associated Listeria monocytogenes Infections.Infect Immun. 2018 Oct 25;86(11):e00397-18. doi: 10.1128/IAI.00397-18. Print 2018 Nov. Infect Immun. 2018. PMID: 30104213 Free PMC article.
-
Pathogen intelligence.Front Cell Infect Microbiol. 2014 Jan 31;4:8. doi: 10.3389/fcimb.2014.00008. eCollection 2014. Front Cell Infect Microbiol. 2014. PMID: 24551600 Free PMC article. Review.
-
Type I-F CRISPR-Cas Distribution and Array Dynamics in Legionella pneumophila.G3 (Bethesda). 2020 Mar 5;10(3):1039-1050. doi: 10.1534/g3.119.400813. G3 (Bethesda). 2020. PMID: 31937548 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
