Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Sep;69(Pt 9):1055-61.
doi: 10.1107/S0108270113019823. Epub 2013 Aug 7.

A new structure of a serotonin salt: comparison and conformational analysis of all known serotonin complexes

Denis Rychkov  1 , Elena V Boldyreva, Nikolay A Tumanov
Affiliations

A new structure of a serotonin salt: comparison and conformational analysis of all known serotonin complexes

Denis Rychkov et al. Acta Crystallogr C. 2013 Sep.

Abstract

Four serotonin salt structures (serotonin adipate, C10H13N2O(+)·C6H9O4(-), is a previously unknown structure) were analysed to understand the influence of the anion on serotonin conformation. Hydrogen bonding alone favours a flat conformation, whereas additional stacking interactions between ions may possibly account for the nonplanar conformation. Since molecular conformation, stability and biological activity are interrelated, one can consider influencing the chemical and biological properties of serotonin by selecting an appropriate counter-ion for salt formation.

Keywords: Hirshfeld surfaces; conformation; crystal structure; hydrogen bonding; serotonin adipate; stacking interactions.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Crystal structure of serotonin.
    Naeem M, Chadeayne AR, Golen JA, Manke DR. Naeem M, et al. Acta Crystallogr E Crystallogr Commun. 2022 Mar 10;78(Pt 4):365-368. doi: 10.1107/S2056989022002559. eCollection 2022 Apr 1. Acta Crystallogr E Crystallogr Commun. 2022. PMID: 35492269 Free PMC article.

Publication types

LinkOut - more resources