Selective serotonin reuptake inhibitors as a novel class of immunosuppressants

doi:10.1016/j.intimp.2014.02.030

Review

. 2014 May;20(1):148-56.

doi: 10.1016/j.intimp.2014.02.030. Epub 2014 Mar 6.

Selective serotonin reuptake inhibitors as a novel class of immunosuppressants

Veerle Gobin¹, Katleen Van Steendam¹, Damiaan Denys², Dieter Deforce³

Affiliations

¹ Laboratory of Pharmaceutical Biotechnology, University of Ghent, Belgium.
² Department of Psychiatry, Academic Medical Centre, University of Amsterdam, The Netherlands; The Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
³ Laboratory of Pharmaceutical Biotechnology, University of Ghent, Belgium. Electronic address: Dieter.Deforce@Ugent.be.

PMID: 24613205
DOI: 10.1016/j.intimp.2014.02.030

Free article

Review

Selective serotonin reuptake inhibitors as a novel class of immunosuppressants

Veerle Gobin et al. Int Immunopharmacol. 2014 May.

Free article

. 2014 May;20(1):148-56.

doi: 10.1016/j.intimp.2014.02.030. Epub 2014 Mar 6.

Authors

Veerle Gobin¹, Katleen Van Steendam¹, Damiaan Denys², Dieter Deforce³

Affiliations

¹ Laboratory of Pharmaceutical Biotechnology, University of Ghent, Belgium.
² Department of Psychiatry, Academic Medical Centre, University of Amsterdam, The Netherlands; The Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
³ Laboratory of Pharmaceutical Biotechnology, University of Ghent, Belgium. Electronic address: Dieter.Deforce@Ugent.be.

PMID: 24613205
DOI: 10.1016/j.intimp.2014.02.030

Abstract

In the past decades, selective serotonin reuptake inhibitors (SSRIs) have been shown to exert several immunological effects, such as reduced lymphocyte proliferation, alteration of cytokine secretion and induction of apoptosis. Based on these effects, SSRIs were proposed as drugs for the treatment of autoimmune pathologies and graft-versus-host disease. This review summarizes preclinical and clinical evidence supporting a role for SSRIs in autoimmune diseases and graft-versus-host disease, and discusses what is known about the mechanism underlying these effects.

Keywords: Autoimmune diseases; Graft-versus-host disease; Immunosuppression; Lymphocytes; Selective serotonin reuptake inhibitors.

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Selective serotonin reuptake inhibitors as a novel class of immunosuppressants

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Selective serotonin reuptake inhibitors as a novel class of immunosuppressants

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