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Review
. 1989 May;73(3):567-82.
doi: 10.1016/s0025-7125(16)30658-7.

Teratology: principles and practice

J M Dicke  1
Affiliations
Review

Teratology: principles and practice

J M Dicke. Med Clin North Am. 1989 May.

Abstract

Gross anomalies of structure and/or function affect 2 to 4 per cent of all human newborns and are the leading cause of perinatal mortality in this country. Despite their significance, the etiology of most such defects remains unclear. A majority are unassociated with any identifiable cause; a small but significant percentage are attributed to heritable disorders of either a Mendelian (single gene) or chromosomal nature. Drugs and environmental exposures are currently implicated in only a small percentage of affected pregnancies. Nevertheless, an awareness of the principles of teratogenesis, an appreciation for the role--though imprecise--of placental transfer and fetal drug disposition, and avoidance of known teratogens currently offers our best hope for the study and prevention of birth defects.

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