Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jun;16(6):360-74.
doi: 10.1038/nrm4002.

DNA replication origin activation in space and time

Michalis Fragkos  1 , Olivier Ganier  2 , Philippe Coulombe  2 , Marcel Méchali  1
Affiliations
Review

DNA replication origin activation in space and time

Michalis Fragkos et al. Nat Rev Mol Cell Biol. 2015 Jun.

Abstract

DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1-S-phase transition, pre-RCs are converted into pre-initiation complexes, in which the replicative helicase is activated, leading to DNA unwinding and initiation of DNA synthesis. However, only a subset of origins are activated during any S phase. Recent insights into the mechanisms underlying this choice reveal how flexibility in origin usage and temporal activation are linked to chromosome structure and organization, cell growth and differentiation, and replication stress.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. EMBO J. 1998 Apr 15;17(8):2426-35 - PubMed
    1. EMBO J. 2006 Nov 1;25(21):5171-9 - PubMed
    1. Nature. 2014 Aug 14;512(7513):198-202 - PubMed
    1. EMBO J. 2008 Nov 19;27(22):3024-35 - PubMed
    1. Mol Biol Cell. 2008 Mar;19(3):1007-21 - PubMed

Publication types

LinkOut - more resources