Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults

doi:10.1016/j.neurobiolaging.2015.05.004

. 2015 Sep;36(9):2568-76.

doi: 10.1016/j.neurobiolaging.2015.05.004. Epub 2015 May 14.

Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults

Affiliations

¹ Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA; Wisconsin Center for Sleep Medicine and Research, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: ksprecher@wisc.edu.
² Geriatric Research Education and Clinical Center, William S. Middleton Memorial VA Hospital, Madison, WI, USA; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
³ Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁴ Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁵ Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁶ Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁷ Geriatric Research Education and Clinical Center, William S. Middleton Memorial VA Hospital, Madison, WI, USA; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁸ Wisconsin Center for Sleep Medicine and Research, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.

PMID: 26059712
PMCID: PMC4523445
DOI: 10.1016/j.neurobiolaging.2015.05.004

Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults

Kate E Sprecher et al. Neurobiol Aging. 2015 Sep.

. 2015 Sep;36(9):2568-76.

doi: 10.1016/j.neurobiolaging.2015.05.004. Epub 2015 May 14.

Authors

Affiliations

¹ Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA; Wisconsin Center for Sleep Medicine and Research, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: ksprecher@wisc.edu.
² Geriatric Research Education and Clinical Center, William S. Middleton Memorial VA Hospital, Madison, WI, USA; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
³ Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁴ Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁵ Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁶ Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁷ Geriatric Research Education and Clinical Center, William S. Middleton Memorial VA Hospital, Madison, WI, USA; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁸ Wisconsin Center for Sleep Medicine and Research, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.

PMID: 26059712
PMCID: PMC4523445
DOI: 10.1016/j.neurobiolaging.2015.05.004

Abstract

Midlife may be an ideal window for intervention in Alzheimer's disease (AD). To determine whether sleep is associated with early signs of AD neuropathology (amyloid deposition) in late midlife, we imaged brain amyloid deposits using positron emission tomography with [C-11]Pittsburgh Compound B (PiB), and assessed sleep with the Epworth Sleepiness Scale and the Medical Outcomes Study Sleep Scale in 98 cognitively healthy adults (aged 62.4 ± 5.7 years) from the Wisconsin Registry for Alzheimer's Prevention. We used multiple regressions to test the extent to which sleep scores predicted regional amyloid burden. Participants reporting less adequate sleep, more sleep problems, and greater somnolence on the Medical Outcomes Study had greater amyloid burden in AD-sensitive brain regions (angular gyrus, frontal medial orbital cortex, cingulate gyrus, and precuneus). Amyloid was not associated with reported sleep amount, symptoms of sleep-disordered breathing, trouble falling asleep, or Epworth Sleepiness Scale. Poor sleep may be a risk factor for AD and a potential early marker of AD or target for preventative interventions in midlife.

Keywords: Alzheimer's disease; Amyloid; Midlife; PET; Self-report; Sleep.

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Figures

**Figure 1**
AAL Regions of Interest. Ang, angular gyrus; CingA, anterior cingulate; CingP, posterior cingulate; FMO, frontal middle orbital gyrus; P, precuneus; SM, supramarginal gyrus; TM, middle temporal gyrus; TS, superior temporal gyrus.

**Figure 2**
Association between sleep scores and mean PiB DVR. Raw data is plotted, regression line is adjusted for age, sex, APOE4, family history of Alzheimer’s disease and body mass index.

See this image and copyright information in PMC

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References

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[1] Ancoli-Israel S, Palmer BW, Cooke JR, Corey-Bloom J, Fiorentino L, Natarajan L, Liu L, Ayalon L, He F, Loredo JS. Cognitive effects of treating obstructive sleep apnea in Alzheimer’s disease: a randomized controlled study. J Am Geriatr Soc. 2008;56:2076–2081. doi: 10.1111/j.1532-5415.2008.01934.x. - DOI - PMC - PubMed

[2] Ancoli-Israel S, Palmer BW, Cooke JR, Corey-Bloom J, Fiorentino L, Natarajan L, Liu L, Ayalon L, He F, Loredo JS. Cognitive effects of treating obstructive sleep apnea in Alzheimer’s disease: a randomized controlled study. J Am Geriatr Soc. 2008;56:2076–2081. doi: 10.1111/j.1532-5415.2008.01934.x. - DOI - PMC - PubMed

[3] Benedict C, Byberg L, Cedernaes J, Hogenkamp PS, Giedratis V, Kilander L, Lind L, Lannfelt L, Schiöth HB. Self-reported sleep disturbance is associated with Alzheimer’s disease risk in men. Alzheimers Dement J Alzheimers Assoc. 2014 doi: 10.1016/j.jalz.2014.08.104. - DOI - PubMed

[4] Benedict C, Byberg L, Cedernaes J, Hogenkamp PS, Giedratis V, Kilander L, Lind L, Lannfelt L, Schiöth HB. Self-reported sleep disturbance is associated with Alzheimer’s disease risk in men. Alzheimers Dement J Alzheimers Assoc. 2014 doi: 10.1016/j.jalz.2014.08.104. - DOI - PubMed

[5] Bero AW, Bauer AQ, Stewart FR, White BR, Cirrito JR, Raichle ME, Culver JP, Holtzman DM. Bidirectional Relationship between Functional Connectivity and Amyloid-β Deposition in Mouse Brain. J Neurosci. 2012;32:4334–4340. doi: 10.1523/JNEUROSCI.5845-11.2012. - DOI - PMC - PubMed

[6] Bero AW, Bauer AQ, Stewart FR, White BR, Cirrito JR, Raichle ME, Culver JP, Holtzman DM. Bidirectional Relationship between Functional Connectivity and Amyloid-β Deposition in Mouse Brain. J Neurosci. 2012;32:4334–4340. doi: 10.1523/JNEUROSCI.5845-11.2012. - DOI - PMC - PubMed

[7] Bero AW, Yan P, Roh JH, Cirrito JR, Stewart FR, Raichle ME, Lee JM, Holtzman DM. Neuronal activity regulates the regional vulnerability to amyloid-β deposition. Nat Neurosci. 2011;14:750–756. doi: 10.1038/nn.2801. - DOI - PMC - PubMed

[8] Bero AW, Yan P, Roh JH, Cirrito JR, Stewart FR, Raichle ME, Lee JM, Holtzman DM. Neuronal activity regulates the regional vulnerability to amyloid-β deposition. Nat Neurosci. 2011;14:750–756. doi: 10.1038/nn.2801. - DOI - PMC - PubMed

[9] Buysse DJ. Sleep health: can we define it? Does it matter? Sleep. 2014;37:9–17. doi: 10.5665/sleep.3298. - DOI - PMC - PubMed

[10] Buysse DJ. Sleep health: can we define it? Does it matter? Sleep. 2014;37:9–17. doi: 10.5665/sleep.3298. - DOI - PMC - PubMed

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Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults

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Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults

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