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Book

Physiology, Carbon Dioxide Retention

Shivani Patel  1 , Julia H. Miao  2 , Ekrem Yetiskul  3 , Anya Anokhin  4 , Sapan H. Majmundar  5
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Physiology, Carbon Dioxide Retention

Shivani Patel et al.
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Excerpt

Carbon dioxide is formed intracellularly in the human body as a byproduct of metabolism. It is transported in the bloodstream to the lungs, where it is ultimately removed from the body through exhalation. CO2 plays various roles in the human body, including regulating blood pH, respiratory drive, and hemoglobin's affinity for oxygen (O2). Fluctuations in CO2 levels are highly regulated and can cause disturbances in the human body if normal levels are not maintained.

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Conflict of interest statement

Disclosure: Shivani Patel declares no relevant financial relationships with ineligible companies.

Disclosure: Julia Miao declares no relevant financial relationships with ineligible companies.

Disclosure: Ekrem Yetiskul declares no relevant financial relationships with ineligible companies.

Disclosure: Anya Anokhin declares no relevant financial relationships with ineligible companies.

Disclosure: Sapan Majmundar declares no relevant financial relationships with ineligible companies.

References

    1. Wong-Riley MT, Liu Q, Gao XP. Peripheral-central chemoreceptor interaction and the significance of a critical period in the development of respiratory control. Respir Physiol Neurobiol. 2013 Jan 01;185(1):156-69. - PMC - PubMed
    1. Putnam RW, Filosa JA, Ritucci NA. Cellular mechanisms involved in CO(2) and acid signaling in chemosensitive neurons. Am J Physiol Cell Physiol. 2004 Dec;287(6):C1493-526. - PubMed
    1. Vasileiadis I, Alevrakis E, Ampelioti S, Vagionas D, Rovina N, Koutsoukou A. Acid-Base Disturbances in Patients with Asthma: A Literature Review and Comments on Their Pathophysiology. J Clin Med. 2019 Apr 25;8(4) - PMC - PubMed
    1. Baillieul S, Revol B, Jullian-Desayes I, Joyeux-Faure M, Tamisier R, Pépin JL. Diagnosis and management of central sleep apnea syndrome. Expert Rev Respir Med. 2019 Jun;13(6):545-557. - PubMed
    1. Bigatello L, Pesenti A. Respiratory Physiology for the Anesthesiologist. Anesthesiology. 2019 Jun;130(6):1064-1077. - PubMed

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