Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2021 Jan;134(1):76-83.e2.
doi: 10.1016/j.amjmed.2020.05.046. Epub 2020 Jul 10.

Association Between Egg Consumption and Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis

Chayakrit Krittanawong  1 , Bharat Narasimhan  2 , Zhen Wang  3 , Hafeez Ul Hassan Virk  4 , Ann M Farrell  5 , HongJu Zhang  5 , W H Wilson Tang  6
Affiliations
Meta-Analysis

Association Between Egg Consumption and Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis

Chayakrit Krittanawong et al. Am J Med. 2021 Jan.

Abstract

Introduction: Considerable controversy remains on the relationship between egg consumption and cardiovascular disease risk. The objective of this systematic review and meta-analysis was to explore the association between egg consumption and overall cardiovascular disease events.

Methods: We systematically searched Ovid MEDLINE, Ovid Embase, Ovid Cochrane Database of Systematic Reviews, Scopus, and Web of Science from database inception in 1966 through January 2020 for observational studies that reported the association between egg consumption and cardiovascular disease events. Two investigators independently reviewed data. Conflicts were resolved through consensus. Random-effects meta-analyses were used. Sources of heterogeneity were analyzed.

Results: We identified 23 prospective studies with a median follow-up of 12.28 years. A total of 1,415,839 individuals with a total of 123,660 cases and 157,324 cardiovascular disease events were included. Compared with the consumption of no or 1 egg/day, higher egg consumption (more than 1 egg/day) was not associated with significantly increased risk of overall cardiovascular disease events (pooled hazard ratios, 0.99; 95% confidence interval, 0.93-1.06; P < .001; I² = 72.1%). Higher egg consumption (more than 1 egg/day) was associated with a significantly decreased risk of coronary artery disease (pooled hazard ratios, 0.89; 95% confidence interval, 0.86-0.93; P < .001; I² = 0%), compared with consumption of no or 1 egg/day.

Conclusions: Our analysis suggests that higher consumption of eggs (more than 1 egg/day) was not associated with increased risk of cardiovascular disease, but was associated with a significant reduction in risk of coronary artery disease.

Keywords: Acute myocardial infarction; Cardiovascular disease; Egg consumption; Meta-analysis; Stroke; Systematic review.

PubMed Disclaimer

Comment in

  • Egg Consumption and Cardiovascular Risk: Limitations of Observational Data.
    Bubb MR. Bubb MR. Am J Med. 2021 Aug;134(8):e465. doi: 10.1016/j.amjmed.2021.03.027. Am J Med. 2021. PMID: 34340753 No abstract available.
  • The Reply.
    Krittanawong C, Narasimhan B, Wang Z, Virk HUH, Farrell AM, Zhang H, Tang WHW. Krittanawong C, et al. Am J Med. 2021 Aug;134(8):e466. doi: 10.1016/j.amjmed.2021.04.011. Am J Med. 2021. PMID: 34340754 No abstract available.
  • Higher Egg Consumption and Cardiovascular Risk.
    Kawada T. Kawada T. Am J Med. 2021 Oct;134(10):e531. doi: 10.1016/j.amjmed.2021.05.025. Am J Med. 2021. PMID: 34593207 No abstract available.
  • The Reply.
    Krittanawong C, Narasimhan B, Wang Z, Virk HUH, Farrell AM, Zhang H, Tang WW. Krittanawong C, et al. Am J Med. 2021 Oct;134(10):e532. doi: 10.1016/j.amjmed.2021.06.009. Am J Med. 2021. PMID: 34593208 No abstract available.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

LinkOut - more resources