doi: 10.1111/j.1751-0813.1988.tb14462.x.
Experimental evidence that tryptamine alkaloids do not cause Phalaris aquatica sudden death syndrome in sheep
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- PMID: 3421887
- DOI: 10.1111/j.1751-0813.1988.tb14462.x
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Experimental evidence that tryptamine alkaloids do not cause Phalaris aquatica sudden death syndrome in sheep
Aust Vet J.
1988 Jul.
Abstract
The acute toxicity for sheep of 3 alkaloids that occur in Phalaris acquatica was examined by intravenous and oral administration. The lowest tested dose rates that produced clinically observed signs were, for 5-methoxy dimethyltryptamine, 0.1 mg/kg body weight intravenously and 40 mg/kg orally; for gramine, 10 mg/kg intravenously and 500 mg/kg orally; and for hordenine, 20 mg/kg intravenously and 800 mg/kg orally. All induced the clinical signs observed in the nervous form of phalaris toxicity, but none induced the cardiac, sudden death, syndrome.
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