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. 1980 Feb 14;283(5748):673-6.
doi: 10.1038/283673a0.

Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone

D A Brown, P R Adams

Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone

D A Brown et al. Nature. .

Abstract

Cholinergic excitation of vertebrate neurones is frequently mediated through the action of acetylcholine on muscarinic (atropine-sensitve) receptors. This type of excitation differs substantially from the better known nicotinic excitation. One difference is that, instead of an increased membrane conductance, a decreased conductance (to K+ ions) frequently accompanies muscarinic depolarisation. This has been detected in sympathetic, cortical and hippocampal neurones. Using voltage-clamped frog sympathetic neurones we have now identified a distinctive voltage-sensitive K+-current, separate from the delayed rectifier current, as the prime target for muscarinic agonists. We have termed this current the M-current, IM.

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