Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993;64(6):389-92.
doi: 10.1007/BF00517943.

Neurotoxicity induced by exposure to toluene. An electrophysiologic study

C Abbate  1 , C Giorgianni, F Munaò, R Brecciaroli
Affiliations

Neurotoxicity induced by exposure to toluene. An electrophysiologic study

C Abbate et al. Int Arch Occup Environ Health. 1993.

Abstract

The object of the present study was to evaluate, with the aid of electrophysiologic techniques, the alterations induced in the auditory nervous system by exposure to toluene in a group of rotogravure workers. From 300 workers who were apparently in good health but were professionally exposed to toluene, we selected a sample of 40 workers of normal hearing ability. They were examined with an adaptation test studied by the brainstem auditory evoked potential technique with 11 and 90 stimulus repetitions a second. The results were compared with those in a group of workers of the same age but not professionally exposed to solvents. Our study demonstrates that exposure to toluene is able to induce a statistically significant alteration in the electric responses with both 11 and 90 stimuli repetitions. This alteration can be explained as a toluene exposure-induced modification, of physiologic stimulus conduction mechanisms, even in the absence of any clinical sign of neuropathy. Furthermore, such a modification could be observed in the electric responses of the entire auditory system, from peripheral receptors to brainstem nuclei.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Br Med J (Clin Res Ed). 1981 Sep 5;283(6292):663-5 - PubMed
    1. Int Arch Occup Environ Health. 1987;59(5):475-83 - PubMed
    1. Br J Ind Med. 1988 Jun;45(6):409-14 - PubMed
    1. Acta Neurol Scand. 1985 Nov;72(5):512-7 - PubMed
    1. Int Arch Occup Environ Health. 1990;62(7):493-9 - PubMed

LinkOut - more resources