| Entry |
|
|---|
| Name |
Landiolol (USAN/INN) |
|---|
| Formula |
C25H39N3O8
|
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| Exact mass |
509.2737
|
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| Mol weight |
509.59
|
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| Structure |
|
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
|
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| Remark |
| Product (DG03235): | D01847<JP/US> |
|
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| Efficacy |
Antiarrhythmic, beta1-Adrenergic receptor antagonist |
|---|
| Comment |
Short-term reduction of ventricular rate in patients with supraventricular tachycardia including atrial fibrillation and atrial flutter
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AB Beta blocking agents, selective
C07AB14 Landiolol
D12410 Landiolol (USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG03235 Landiolol
D12410 Landiolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG03235 Landiolol
D12410 Landiolol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB1
D12410 Landiolol (USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG03235 Landiolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG03235 Landiolol
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 36
1 C1y C 11.9083 -18.3527
2 C1x C 10.9276 -17.3720
3 O2x O 9.6667 -18.0025
4 C1z C 9.8769 -19.3334
5 O2x O 11.2778 -19.5435
6 C1a C 9.8769 -20.7344
7 C1a C 8.4759 -19.3334
8 C8x C 19.1934 -15.5508
9 C8x C 19.1934 -14.1498
10 C8y C 17.9325 -16.2513
11 C8y C 17.9325 -13.4493
12 C8x C 16.7416 -15.5508
13 C8x C 16.7416 -14.1498
14 O2a O 17.9325 -12.0483
15 C1b C 19.1934 -11.3478
16 C1c C 20.3842 -12.0483
17 C1b C 21.5750 -11.3478
18 N1b N 22.8359 -12.0483
19 C1b C 24.0267 -11.3478
20 C1b C 25.2175 -12.0483
21 O1a O 20.3842 -13.4493
22 N1b N 26.4084 -11.3478
23 C5a C 27.6692 -12.0483
24 O5a O 28.8601 -11.3478
25 N1y N 27.6692 -13.4493
26 C1b C 17.9325 -17.6522
27 C1x C 26.4084 -14.1498
28 C1x C 26.4084 -15.5508
29 O2x O 27.6692 -16.2513
30 C1x C 28.8601 -15.5508
31 C1x C 28.8601 -14.1498
32 C1b C 16.7416 -18.3527
33 C7a C 15.5508 -17.6522
34 O7a O 14.2899 -18.3527
35 C1b C 13.0991 -17.6522
36 O6a O 15.5508 -16.2513
BOND 38
1 3 4 1
2 4 5 1
3 5 1 1
4 18 19 1
5 12 13 1
6 19 20 1
7 20 22 1
8 16 21 1 #Down
9 11 14 1
10 8 9 2
11 14 15 1
12 22 23 1
13 23 24 2
14 8 10 1
15 23 25 1
16 15 16 1
17 10 26 1
18 9 11 1
19 16 17 1
20 10 12 2
21 17 18 1
22 11 13 2
23 25 27 1
24 27 28 1
25 28 29 1
26 29 30 1
27 30 31 1
28 31 25 1
29 4 6 1
30 26 32 1
31 32 33 1
32 4 7 1
33 33 34 1
34 1 2 1
35 34 35 1
36 2 3 1
37 33 36 2
38 1 35 1 #Up
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